Key points in physiology of
ENDOCRINOLOGY
ππππ
π Insulin increases:
✅ Glycogen synthesis,
✅Fat synthesis,
✅Protein synthesis etc.
π Insulin is a: Hypoglycemic hormone
πInsulin is secreted by: Beta cells of pancreas
π In fetus, secretion of insulin begins by: 3 months
π Insulin secretion is inhibited by: Epinephrine
π Delta cells of pancreas secrete: Somatostatin
π Hormones acting on intracellular nuclear receptors:
✅Steroids,
✅ Thyroid hormones,
✅ Vitamin D etc.
πcAMP mediates action of:
✅ ADH,
✅PTH etc.
π cGMP mediates action of: NO (cellular signalling molecule)
πInsulin acts throught: Tyrosine kinase activity
π Hormones belonging to steroid receptor family:
✅Vitamin D3,
✅Thyroid
πEffect of parathormone:
✅ Stimulates osteoclastic activity,
✅ Augments absorption of calcium from the gut
πEffect of calcitonin:
✅ Opposite to that of PTH,
✅ Lowers serum calcium,
✅ Acts by decreasing osteoclasis (bone resorption)
πActive form of calcium: Ionized form
πA decrease in concentration of free calcium ions in plasma results in:
✅Increased neuromuscular irritability & tetani,
✅ Chvostek's sign etc.
πECG finding of hypocalcemia: Lengthening of the QT interval
πACTH & TSH are secreted by: Anterior pituitary gland
π Vasopressin & oxytocin are released by: Posterior pituitary gland